HiMice
Toxicology studies that help to determine the toxicity profile of a new compound are a standard practice in the safety evaluation of new drugs and products. Livingsciences can conduct standard in vitro and in vivo toxicology studies and work with clients to develop novel toxicology study designs.
Customization
HiMice are a humanised mouse model with a stably reconstituted human immune system. As HiMice express the human immune system, they are an ideal in vivo animal model for research in human immunology, oncology, inflammation and infectious diseases.
Available customization:
| Cytokine Plasmids | Function |
| IL-15 | Improve T-cell and NK-cell differentiation and proliferation |
| GM-CSF | Improved granulocyte, monocyte, macrophage and eosinophils differentiationical exposure to a predetermined 4-concentration range of test chemicals |
| IL-4 | Increased T and B lymphocyte proliferation |
| IL-3 | Improved proliferation of a broad range of hematopoietic cell types |
| M-CSF | Improved macrophage differentiation and proliferation |
| IL-7 | Increase T-cell development |
